J Pharm Sci. Adjust dosage at intervals of ≥4 weeks until the desired effect on lipoprotein concentrations is observed or a daily dosage of 20 mg is reached. atorvastatin calcium trihydrate: ChEBI ID CHEBI:2911: Definition A hydrate that is the trihydrate form of atorvastatin calcium. Three atorvastatin-loaded formulations (FA1-FA3) were prepared by using varying polymer ratios of 1:1, 1:3, 1:5, and other excipients like starch, talc, and lactose. Request PDF | New Category for Active Pharmaceutical Ingredients, a Low Molecular Weight Organogelator: Crystal Structure of Atorvastatin Calcium and Its … PS. *Please select more than one item to compare fer 1 Tablet to a volumetric flask of such capacity that when Atorvastatin Calcium filled to volume, a concentration of about 0.25 mg of chlorthal-idone per mL is obtained. Grapefruit and grapefruit juice may interact with atorvastatin and lead to potentially dangerous effects. It is therefore important to know the dose-related magnitude of effect of atorvastatin on blood lipids. Atorvastatin calcium,physical properties,suppliers,CAS,MSDS,structure,Molecular Formula, Molecular Weight ,Solubility,boiling point, melting point Home Products Search Properties Search 中文版: Home > Dictionary > Information: Atorvastatin calcium Molecular formula : (C 33 H 34 FN 2 O 5) 2. 2017;106:1586–95. Objectives: To quantify the dose-related effects of atorvastatin on blood lipids and withdrawals due to adverse effects (WDAE). Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. 1 65. atorvastatin calcium contains an excipient [ an inactive ingredient in the form of calcium carbonate] and is equally effective in treating/reducing cholesterol and can be used instead of atorvastatin. Characterization of the pore structure of functionalized calcium carbonate tablets by terahertz time-domain spectroscopy and X-ray computed microtomography. The Atorvastatin Calcium Tablets Revision Bulletin supersedes the monograph that will be official in USP 41–NF 36. Atorvastatin was marketed as its calcium salt (2:1) in crystalline trihydrate designated Form I under the brand ... which a solvent(s) “is coordinated in or accommodated by the crystal structure” [GRI06]. Minimize drinking alcohol. Stars This entity has been manually annotated by … Atorvastatin Calcium contains NLT 98.0% and NMT 115 100 0 102.0% of atorvastatin calcium (C 66H 68CaF 2N 4O 10), calcu- Diluent: N,N-dimethylformamide lated on the anhydrous •.and solvent-free basis. The crystal structure of atorvastatin calcium trihydrate (ACT) has been solved and refined using syn-chrotron X-ray powder diffraction data and optimized using density functional theory techniques. Should you haveany questions, please contact Sujatha Ramakrishna, Principal Scientific Liaison (301-816-8349 or sxr@usp.org). Atorvastatin 6 (Figure 7) is a synthetic statin that contains an unusual penta-substituted pyrrole ring in place of the hexahydronaphthalene found in the early statins.The rationale for optimization employed a combination of insights from molecular modeling and hypothesis-based chemistry to define key structure–activity relationships. Size Price Stock; 1 mg USD 150 Ask For Quote & Lead Time or * Please select Quantity before adding items. Crystal structure of atorvastatin calcium trihydrate Form I (Lipitor ® ), (C 33 H 34 FN 2 O 5 ) 2 Ca(H 2 O) 3. A new 43Ca NMR crystallographic approach which includes an exten 2019 PCCP HOT Articles They received atorvastatin 10 mg every other day before bedtime. The crystal structure of atorvastatin calcium ethylene glycol solvate suggests atorvastatin calcium to be a low-molecular weight organogelator that forms organogels with a wide variety of alkyl alcohols. … Background: Atorvastatin is one of the most widely prescribed drugs and the most widely prescribed statin in the world. 1907/2006 as amended by (EC) No. 344423-98-9 - SHZPNDRIDUBNMH-NIJVSVLQSA-L - Atorvastatin calcium trihydrate - Similar structures search, synonyms, formulas, resource links, and other chemical information. 2015/830 and US OSHA HCS 2015 1.1 Product Code: 10493 Section 1. The Atorvastatin calcium, with the CAS registry number 134523-03-8, is also known as CI 981. 1. CAS No. 134523-03-8 - FQCKMBLVYCEXJB-MNSAWQCASA-L - Atorvastatin calcium [USAN:USP] - Similar structures search, synonyms, formulas, resource links, and other chemical information. C181417-M6340-CHM22015, rev. Atorvastatin calcium C66H68CaF2N4O10 structure Molecular Formula C66H68CaF2N4O10 Average mass 1155.342 Da Density Boiling Point Flash Point Molar … Available as atorvastatin calcium; dosage expressed in terms of atorvastatin. â Correspondence: Dr. J. Ulrich (joachim.ulrich@iw.uni-halle.de), Zentrum für Ingenieurwissenschaften, Verfahrenstechnik/TVT, MartinLuther-Universität Halle-Wittenberg, D-06099 Halle, Germany. 00 20180427. Chemical structure of atorvastatin calcium (ATC). Atorvastatin is the most potent statin and has a long half-life. Therefore, atorvastatin given on alternate days may be reasonable and cost effective, particularly in hypercholesterolemia patients. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol. Since atorvastatin trihydrate calcium is highly unstable ... Karttunen AP, Chakraborty M, Bawuah P, et al. This chemical's molecular formula is C 2-Hydroxy atorvastatin calcium salt Chemical Structure. Ca; C 66 H 68 CaF 2_ sN 4 O 10 MW : No. as processes that generate amorphous forms. Atorvastatin is marketed as its calcium salt in crystalline trihydrate. Pediatric Patients Dyslipidemias Heterozygous Familial Hypercholesterolemia Oral Children 10–17 years of age: Initially, 10 mg once daily. Atorvastatin calcium is [R-(R*, R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1Hpyrrole-1-heptanoic acid, calcium salt (2:1)trihydrate. Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol. It can raise triglyceride levels and may increase your risk of liver damage. The empirical formula of atorvastatin calcium is(C 33 H 34 FN 2 O 5)2Ca•3H 2 O and its molecular weight is 1209.42. Atorvastatin (calcium salt) SAFETY DATA SHEET Supersedes Revision: 08/02/2018 according to Regulation (EC) No. Atorvastatin calcium,physical properties,suppliers,CAS,MSDS,structure,Molecular Formula, Molecular Weight ,Solubility,boiling point, melting point Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Atorvastatin (calcium salt) Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. Surprisingly, in an extensive literature survey, atorvastatin calcium (ATC) is found … Add a mixture of water and acetoni-trile (1:1) to about half the capacity of the flask, and shake by mechanical means for not less than 15 minutes to disintegrate the Tablet. ACT crystallizes in space group P1 (#1) with a=5.44731(4), b=9.88858(16), c=29.5925(10) Å, α=95.859(3), β=94.211(1), γ=105.2790(1)°, V=1521.277(10) Å3, and Z=1. Compare Products: Select up to 4 products. Atorvastatin calcium tablet is an HMG-CoA reductase inhibitor indicated as an adjunct therapy to diet to: Reduce the risk of MI, stroke, revascularization procedures, and angina in adult patients without CHD, but with multiple risk factors . Method and result: Sixty patients with hypercholesterolemia despite diet therapy were enrolled into the study. ; Reduce the risk of MI and stroke in adult patients with type 2 diabetes without CHD, but with multiple risk factors (1.1). Search results for Atorvastatin calcium at Sigma-Aldrich. Biological Activity; Purity & Documentation; References; Customer Review; Description: 2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. CAS PubMed Google Scholar 15. Dilute with water to volume, and mix. The Revision Bulletin will be incorporated in USP 42–NF 37. We combine experimental and computational determination of 43Ca solid-state NMR parameters (chemical shift tensors, quadrupolar coupling tensors, and Euler angles) to constrain the structure of the local calcium–ligand coordination environment. 1. Atorvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. The formulations were evaluated for hardness, friability, weight variation, disintegration, and in vitro release study. It belongs to the product categories of Active Pharmaceutical Ingredients; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Atorvastatin. However, the sky soaring demand of ATC and an interesting structure of this drug directed the pharmaceutical scientist towards a high number of patents and many publications offering different crystalline forms as well as processes to generate alternative forms . Zhou M, Shen L, Lin X, Hong Y, Feng Y. April 2020 : 265989-46-6 . The infrared absorption spectrum of atorvastatin calcium, Form-I, was obtained using a Nicolet FT-IR Impact 410 spectrophotometer equipped with deuterated triglycine sulfate detector, and using Omnic 5.1a software.The sample was contained in a pressed KBr pellet, with each spectrum being derived from 16 single scans over the range of 4000–400 cm –1 at a spectral resolution of 2 cm –1. In case the solvent is water, the solid form is named hydrate.
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